Triple Retinoid Serum

SEGLE Biotech Triple Retinoid Serum is a next-generation global anti-aging nighttime treatment, formulated for those who demand clinically proven results in wrinkles, firmness, texture, dark spots, and pores. Its secret lies in a powerful synergy of three retinoids (pure retinol, pure retinal, and liposomed marine retinal) reinforced with niacinamide, centella asiatica, licorice, and vitamin E, which work in harmony to transform the skin without sacrificing comfort or sensory elegance. Night after night, the face regains definition, luminosity, and a refined texture characteristic of a professional high-cosmetics routine.

Intensive global anti-aging treatment

This serum has been designed as an advanced nighttime protocol to simultaneously address multiple signs of aging and skin imbalance:

• Visible reduction of fine wrinkles and expression lines from 28 days of use.
• Clinically proven improvement in skin firmness and elasticity, with an increase of up to +55% after 12 weeks.
• Refines texture and minimizes the size of pores, delivering a smoother, more even skin surface.
• Unifies skin tone, adds luminosity, and helps reduce spots associated with photoaging.
• Sebum-regulating, soothing, and anti-inflammatory action, suitable for combination, oily, and even skin prone to acne or rosacea.
• Powerful antioxidant effect that helps protect against oxidative stress and environmental damage.

Triple Retinoid: three retinoids, one same mission

The heart of the formula is made up of a carefully balanced trio of retinoids to maximize efficacy and tolerability. Each one adds a distinct nuance to the serum’s overall action:

Pure Retinol 0.3% – The anti-aging gold standard

Retinol is one of the most studied active ingredients in cosmetic dermatology and is considered the “gold standard” in anti-aging treatments.

• Stimulates the production of collagen and elastin, softening wrinkles and expression lines.
• Promotes epidermal renewal, improving texture and delivering a more uniform and radiant appearance.
• Helps reduce spots and tone changes caused by the sun and the passage of time.
• Regulates excess sebum, making it especially useful for combination skin or skin prone to acne.

Pure Retinal 0.15% – Power and rapid action

Retinal (retinaldehyde) is a more direct and potent vitamin A derivative than retinol, because it requires only a single conversion step to turn into retinoic acid in the skin.

• Intensely stimulates the synthesis of collagen and elastin, improving firmness and elasticity in less time.
• Accelerates cell turnover, refining skin grain, improving luminosity, and homogenizing tone.
• Helps reduce dark spots and discoloration, restoring a more even look.
• Provides a slight antibacterial action, interesting for skin with imperfections or adult acne.

Liposomed Marine Retinal 1% – Blue biotechnology with high tolerability

Liposomed marine retinal comes from a complex of encapsulated carotenoid compounds extracted from the microalga Chlorella vulgaris, grown using blue biotechnology.

• Acts with the same mechanism as pure retinal, but with higher skin tolerance thanks to its encapsulation.
• Refines texture, smooths irregularities, and helps achieve smoother, more even-looking skin.
• Stimulates collagen and elastin, reducing wrinkles and sagging.
• Adds overall radiance and helps unify the face’s tone.
• Provides protection against oxidative and environmental stress, strengthening the skin’s resilience.

Soothing and perfection complex

To complement the intensity of the triple retinoid technology, the Triple Retinoid Serum features dermo-compatible actives that calm, protect, and perfect the skin:

5% Niacinamide – Balance, evenness, and a strengthened barrier

Niacinamide (vitamin B3) is a multi-action ingredient that masterfully complements the effect of retinoids.

• Helps reduce dark spots and chromatic irregularities, promoting a more even-looking tone.
• Soothes redness and irritation, improving comfort on reactive skin.
• Regulates excess sebum and visually minimizes pores.
• Strengthens the skin barrier by stimulating ceramide synthesis, increasing hydration and elasticity.
• Provides additional antioxidant protection against free radicals.

Centella Asiatica Extract – Repair and firmness

Centella Asiatica is a plant revered for its repairing, soothing, and anti-inflammatory properties.

• Stimulates collagen synthesis, contributing to firmer, more elastic skin.
• Accelerates skin repair processes and improves the appearance of damaged skin.
• Soothes redness and reduces the feeling of irritation.
• Provides antioxidant action, helping prevent premature aging.

Licorice Extract – Depigmenting and anti-inflammatory

Licorice root extract, rich in glabridin, is a key ally in treatments for uneven tone and sensitivity.

• Helps lighten dark spots and hyperpigmentation, unifying the tone.
• Soothes the skin and reduces redness thanks to its anti-inflammatory action.
• Protects against oxidative damage caused by UV radiation and pollution.
• Especially beneficial for sensitive skin or skin that tends to get irritated.

Vitamin E – Essential antioxidant shield

Vitamin E (Tocopheryl Acetate) provides additional antioxidant defense and strengthens skin integrity.

• Neutralizes free radicals, slowing accelerated aging.
• Reinforces the skin barrier, helping to maintain hydration.
• Helps calm mild irritations and reduce redness.
• Boosts the action of other antioxidants present in the routine.

Night application ritual

How to incorporate it into your routine

• Initial frequency: start with 1–2 nights per week on clean, completely dry skin, avoiding the eye contour and lips.
• Progression: if your skin shows good tolerance, increase to 2–3 nights per week during the following weeks, and then gradually raise it until reaching your desired frequency.
• How to use: apply a small amount of Triple Retinoid Serum to the face and neck, and, if desired, the décolletage, spreading it with gentle movements until fully absorbed.
• Comfort layers: 20 minutes later, it is recommended to apply a soothing and regenerating product (such as a serum or cream with growth factors, barrier support, or centella) to enhance hydration and the skin barrier function, especially for dry or sensitive skin.
• Sun protection: in the morning, it is essential to use a broad-spectrum sunscreen, even on cloudy days, to protect the renewed skin and preserve the results.

Usage recommendations by skin type

• Combination or oily skin: excellent option for treating enlarged pores, uneven texture, and acne-prone tendency, while keeping the skin balanced and refined.
• Normal or mature skin:
• Sensitive skin or with rosacea:
• Advanced users of retinoids:

Full list of ingredients (INCI)

AQUA (WATER), PROPANEDIOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, C12-15 ALKYL BENZOATE, GLYCERIN, NIACINAMIDE, RETINOL, RETINAL, CHLORELLA VULGARIS EXTRACT, TOCOPHERYL ACETATE, GLYCYRRHIZA GLABRA ROOT EXTRACT, CENTELLA ASIATICA EXTRACT, HYDROGENATED LECITHIN, LECITHIN, CARBOMER, SODIUM HYDROXIDE, SODIUM GLUCONATE, ETHYLHEXYLGLYCERIN, 1,2-HEXANEDIOL, CAPRYLYL GLYCOL, PHENOXYETHANOL, PARFUM (FRAGRANCE).

The Triple Retinoid Serum embodies the most advanced vision of biotechnological cosmetics: a precise, demanding, and deeply transformative formula, created for those who view skincare as an investment ritual over the long term in youthfulness, radiance, and conscious beauty.