The Skin Biotic

The Skin Biotic is a next-generation nutricosmetic designed to precisely modulate the gut microbiome and, through the gut–skin axis, actively support skin health from within. Its formula combines a carefully dosed prebiotic, three patented probiotic strains and highly bioavailable forms of retinol and D-biotin, acting on the physiological mechanisms behind inflammation, immune dysregulation and skin imbalances.

With a systemic, integrative approach, The Skin Biotic helps restore the overall homeostasis of the body and skin, making it especially interesting for profiles prone to inflammation (acne, rosacea, atopic dermatitis, sensitive skin) and for those looking to preserve skin longevity against intrinsic ageing and external factors.

Key benefits for the skin

• Gut–skin axis balance: modulates the gut and skin microbiome, promoting a more diverse and resilient microbial ecosystem.
• Reduced inflammation: helps ease inflammatory processes involved in acne, rosacea, eczema, atopic dermatitis and reactive skin.
• Stronger skin barrier: improves the integrity of the stratum corneum and barrier function, reducing transepidermal water loss and sensitivity.
• Hydration and comfort: stimulates the natural production of hyaluronic acid and essential lipids, giving the skin a plumper, more elastic and comfortable feel.
• Overall anti-ageing effect: helps minimise the appearance of wrinkles and fine lines, improves texture and enhances radiance, protecting against oxidative damage.
• Support for regeneration: promotes tissue repair processes and skin recovery after external aggressions or inflammatory flare-ups.

Clinically supported results (8 weeks)

In clinical studies conducted over 8 weeks, following standardised protocols and measurement techniques accepted in the cosmetic field, The Skin Biotic has shown significant results in key parameters of skin quality.

• 88% of subjects showed a significant reduction in wrinkles and fine lines.
• 100% of subjects showed a noticeable increase in skin radiance.
• 96% of subjects experienced improved skin hydration.
• 79% of subjects showed visibly smoother skin.
• 71% of subjects showed improved barrier function.
• 88% of subjects showed a decrease in impurities and imperfections.

These results were obtained within a study design comparing placebo, internal supplementation, topical treatments and the combination of both, supporting The Skin Biotic's "inside-out" approach.

Precision probiotic technology

The heart of The Skin Biotic lies in its probiotic complex, made up of three patented strains selected through genetic analysis and specific trials. Beyond genus level, efficacy is defined at strain level, so the formulation relies on correct integration and dosing, in line with reference clinical studies.

• Lactiplantibacillus plantarum AW001: helps increase the natural production of hyaluronic acid, supporting deep, sustained hydration. It promotes the synthesis of essential lipids and proteins that reinforce the skin's protective layer, reducing vulnerability to irritants and external aggressors. It modulates the skin's immune response, helping to reduce allergic reactions and dysregulated immune processes. Its soothing action is especially interesting for atopic dermatitis and sensitive skin. It also exerts antimicrobial activity against potentially pathogenic bacteria involved in acne and other skin infections, contributing to a healthier microbiome. Its antioxidant properties help protect skin cells from free radical damage, reducing signs of ageing and photostress.
• Limosilactobacillus reuteri AW002: plays a key role in reducing oxidative stress in skin cells, a determining factor in skin ageing. This effect translates into fewer wrinkles and other signs of ageing. It promotes tissue regeneration and skin repair processes after mechanical, chemical or environmental damage. It shows a marked anti-inflammatory action, useful in acne, eczema and psoriasis, thanks to the production of compounds such as reuterin and histamine, capable of modulating the immune response. It also boosts barrier function by increasing ceramides, essential lipids that help retain hydration and keep the skin protected against irritants and pathogens.
• Lacticaseibacillus rhamnosus AW003: specifically reinforces the tight junctions of the epidermis, essential for a competent skin barrier against allergens and pollutants. It modulates the immune response, reducing allergic and inflammatory reactions, and is especially interesting in eczema and atopic dermatitis. It helps balance the skin microbiome, inhibiting the growth of harmful bacteria and promoting a more stable and resistant flora. Its anti-inflammatory properties help soothe inflamed, reddened skin, with benefits observed in acne and rosacea. It also improves the skin's ability to retain water, reducing dryness, and its antioxidant action protects against oxidative stress, slowing environment-induced ageing.

Synergy of prebiotic, retinol and D-biotin

The Skin Biotic's formulation goes beyond simply incorporating probiotics, relying on supporting ingredients that enhance its effect and ensure optimal integration with the body's physiology.

• Fructo-oligosaccharides: act as a prebiotic, serving as a specific substrate for beneficial bacteria. They promote the growth and activity of the probiotic strains present in the formula, improving the stability of the gut microbiome and, as a result, the signals it sends to the skin.
• Retinol (Vitamin A, retinyl acetate): stimulates skin cell renewal from within, improving skin texture and tone. It accelerates the physiological shedding of dead cells and promotes the generation of new cells, acting on gene expression related to skin health. It supports collagen synthesis, helping to reduce the appearance of wrinkles and improve firmness. Its antioxidant action provides protection against environmental stress, UV radiation and pollution, helping to even out tone and reduce hyperpigmentation and age spots.
• D-biotin (Vitamin B8): is essential for the production of fatty acids that form part of cell membranes and the skin's lipid barrier. It takes part in fat metabolism and cell growth, supporting the integrity, hydration and healthy appearance of skin tissue. It may help reduce inflammation and redness, providing additional support in conditions such as rosacea and eczema.
• Mannitol: is included as a sweetener and functional excipient, contributing to a pleasant intake experience and product stability without compromising the quality of the metabolic profile.

Scientific and formulation commitment

The Skin Biotic is developed under pharmaceutical-grade research and production standards. The in-house nutraceutical manufacturing line operates in a GMP (Good Manufacturing Practice) plant certified by the Italian Medicines Agency, which guarantees quality control, traceability and viability of the probiotic strains up to the indicated expiry date.

The dose of each ingredient is defined not by excessive amounts, but by the optimal balance demonstrated in clinical studies. The number of colony-forming units (CFU) of the probiotic strains is adjusted to the levels used in efficacy trials, prioritising results and tolerance over simply "more is better".

The formula is clinically tested, lactose-free, gluten-free, vegan-friendly and committed to using renewable and local sources whenever possible.

How to use

Take 1 sachet a day, preferably in the morning, about 30 minutes before breakfast. It can be taken directly in the mouth or dissolved in a small amount of water, according to personal preference.

For optimal results, continuous use for a minimum of 8 weeks is recommended, incorporating it as part of a comprehensive skincare routine, both internal and topical. It can be used alone or in combination with specific dermocosmetic protocols.

Skin profiles and needs

• Skin prone to inflammation: acne, rosacea, eczema, atopic dermatitis and reactive skin.
• Sensitive skin or weakened barrier, prone to irritation and redness.
• People looking for a preventive strategy to maintain skin youthfulness.
• Dull, dehydrated skin or uneven texture requiring an overall improvement from within.
• Systemic support in advanced care protocols, combining supplementation and topical treatments.

Full ingredients

Full composition:

• Fructo-oligosaccharides
• Sweetener: mannitol
• Limosilactobacillus reuteri (L. reuteri AW002)
• Lacticaseibacillus rhamnosus (L. rhamnosus AW003)
• Lactiplantibacillus plantarum (L. plantarum AW001)
• Vitamin A (retinyl acetate)
• Biotin (D-biotin)